The 2 measuers of interest for this analysis are the Autobiographical Memory Test (AMT) and the and the Revised NEO Personality Inventory (NEO PI-R).

1 Data cleaning

For all analyses, subjects were excluded that had:

no NEO-PI and no AMT data.
no NEO-PI and only baseline AMT data.

The remaining number of subjects is 79, which was used for descriptive statistics. There were 78 subjects with at least 2 AMT measures and 76 subjects had NEO-PI-R data.

2 Descriptives

2.1 Table 1

Characteristic	Active TBS	Sham TBS	P
	N = 42	N = 37
Demographics
Gender (% Female)	29 (69)	27 (73)	0.893
Age, y	66.8 ± 4.4	67.4 ± 7.5	0.650
White - no. (%)	37 (88)	26 (70)	0.057
Years of education - mean (SD)	12.9 ± 3.8	12.9 ± 5.4	0.971
At least 3 minimum wages - no. (%)	21 (50)	20 (54)	0.893
Retired - no. (%)	28 (67)	23 (62)	0.856
Clinical characteristics
Hypertension - no. (%)	18 (43)	16 (43)	1.000
Hypothyroidism - no. (%)	9 (21)	5 (14)	0.393
Onset age of MDD, years - mean (SD) *	41.1 ± 15.2; N=33	44 ± 19.5; N=30	0.510
No. previous depressive episodes - median (IQR) *	3 (1-4); N=32	3 (2-4); N=30	0.985
Duration of current episode, months - mean (SD) *	36.7 ± 39.7; N=33	27.5 ± 33.4; N=30	0.326
Scales at baseline
HDRS-17	20.9 ± 3.1	21.4 ± 3.5	0.572
MADRS	27.4 ± 6.2	27.8 ± 6.3	0.748
Geriatric Depression Scale (GDS)	8.8 ± 1.6	8.8 ± 1.4	0.988
Mania (YMRS)	1.7 ± 1.7	1.7 ± 1.3	0.966
Positive affect (PANAS)	26 ± 5.8	25 ± 4.4	0.395
Negative affect (PANAS)	24.6 ± 6.1	23.9 ± 5.3	0.590
Clinical Global Impression (CGI-1)	4.3 ± 1	4.3 ± 1	0.876
Cumulative Illnes (G-CIRS)	4.2 ± 3.3	3.4 ± 2.7	0.229
AMT Total	32.4 ± 6.5; N=41	30.8 ± 6.4	0.275
AMT positive	11.2 ± 1.8; N=41	10.6 ± 2.3	0.239
AMT negative	11.4 ± 2; N=41	10.5 ± 2.6	0.082
AMT Total	9.8 ± 3.5; N=41	9.7 ± 2.8	0.857

Notes: N is provided where it deviates from the regular sample N. There were no cases of hyperthyroidism.

2.2 NEO PI-R

NEO PI-R was collected at week 6. It was not included in Table 1, which commonly only includes baseline data.

Characteristic	Active TBS	Sham TBS	P
	N = 40	N = 36
Neuroticismo	107.1 ± 14.7	106.7 ± 12.5	0.911
Extroversao	95.7 ± 15.8	93.5 ± 12.2	0.493
Abertura	107.2 ± 16.6	97.8 ± 14.6	0.012
Amabilidade	120.7 ± 12.5	116 ± 10.4	0.079
Conscienciosidade	111.3 ± 15.3	109.1 ± 13.1	0.503
Neuroticismo ansiedade	18.6 ± 3.4	18.5 ± 2.7	0.834
Neuroticismo raiva	16.9 ± 3.6	17.9 ± 3.4	0.212
Neuroticismo depressao	19.6 ± 4.2	19.4 ± 3.1	0.762
Neuroticismo embaraco	19 ± 3.6	17.5 ± 3.2	0.062
Neuroticismo impulsividade	16.3 ± 4.4	16.2 ± 3	0.952
Neuroticismo vulnerabilidade	16.4 ± 3.7	17.2 ± 3.7	0.336
Extroversao acolhimento	20.1 ± 4.5	19 ± 3.8	0.270
Extroversao gregarismo	13.9 ± 4.7	14.7 ± 3.6	0.461
Extroversao assertividade	14.1 ± 3.7	14.1 ± 3.4	0.986
Extroversao atividade	14.6 ± 3.5	15.1 ± 3	0.497
Extroversao busca de sensacoes	16.5 ± 3.3	15.9 ± 2.7	0.423
Extroversao emocoes positivas	16.5 ± 4.8	14.7 ± 4	0.075
Extroversao emocoes positivas extroversao	40 ± 10.5	36.2 ± 8.9	0.097
Abertura fantasia	17.4 ± 4.3	15.1 ± 3.9	0.018
Abertura estetica	19.6 ± 4	17.6 ± 3.4	0.021
Abertura sentimento	18.4 ± 3.2	17.2 ± 3.1	0.092
Abertura acoes variadas	14.7 ± 3.7	14.6 ± 3.3	0.965
Abertura ideias	17.9 ± 4.4	16.2 ± 4.9	0.126
Abertura valores	19.3 ± 3.5	17.1 ± 3.5	0.008
Amabilidade confianca	17.9 ± 4.7	17.9 ± 3	0.966
Amabilidade franqueza	20.5 ± 3	20.2 ± 3.2	0.670
Amabilidade altruismo	21.9 ± 3.3	20.6 ± 3.4	0.100
Amabilidade complacencia	18.7 ± 3.4	16.8 ± 3	0.012
Amabilidade modestia	20.2 ± 2.5	19.6 ± 3	0.374
Amabilidade sensibiliidade	21.6 ± 2.8	20.9 ± 3.3	0.376
Conscienciosidade competencia	19.6 ± 3.2	18.8 ± 3.2	0.248
Conscienciosidade ordem	17.8 ± 4.3	16.9 ± 3	0.276
Conscienciosidade senso de dever	22.7 ± 3	22.6 ± 3.1	0.896
Conscienciosidade esforco por realizacoes	17.9 ± 3.6	17.6 ± 3.9	0.760
Conscienciosidade autodisciplina	15.3 ± 4.3	16.2 ± 2.9	0.310
Conscienciosidade ponderacao	18 ± 4.3	16.6 ± 4.6	0.160

Notes: Some significant findings were expected because of the amount of tests. Most notable is probably the difference in openness (abertura), which differed between groups even on the level of the combined scale.

3 Figures

All error bars represent 95% confidence intervals.

3.1 Longitudinal plots (HDRS & AMT)

3.2 Response and Remission (HDRS)

Condition	Type	Week 1	Week 2	Week 4	Week 6	Week 8	Week 12
Active TBS	HDRS remission - no. (%)	1 (2)	3 (7)	5 (12)	8 (20)	13 (32)	14 (34)
Sham TBS	HDRS remission - no. (%)	3 (8)	1 (3)	1 (3)	4 (11)	7 (20)	7 (19)
Active TBS	HDRS response - no. (%)	4 (10)	8 (19)	12 (29)	16 (39)	20 (49)	20 (49)
Sham TBS	HDRS response - no. (%)	3 (8)	4 (11)	6 (17)	10 (28)	13 (37)	11 (31)

4 Statistical analysis

4.1 TBS effects on AMT

For each AMT measure, a separate linear mixed model was fit. All time points where AMT data was collected (baseline, weeks 4 and 12) were included. The AMT measure was the outcome, while time and condition were included as interacting fixed effects, and subject as a random effect (random intercept). A significant interaction would indicate that treatment had an effect on the AMT measure.

Scale	Effect	Estimate	SE	t	DF	P	Cohen's d
TOTAL TMA	Main effect	0.06	0.70	0.09	149.02	0.932	0.01 [-0.31, 0.34]
	Interaction	-0.24	0.97	-0.25	150.26	0.803	-0.04 [-0.36, 0.28]
TOTAL TMA POS	Main effect	0.09	0.20	0.44	147.46	0.660	0.07 [-0.25, 0.4]
	Interaction	-0.26	0.28	-0.92	148.44	0.358	-0.15 [-0.47, 0.17]
TOTAL TMA NEG	Main effect	0.14	0.20	0.70	146.52	0.486	0.12 [-0.21, 0.44]
	Interaction	-0.14	0.28	-0.50	147.38	0.621	-0.08 [-0.4, 0.24]
TOTAL TMA NU	Main effect	0.32	0.24	1.34	148.03	0.182	0.22 [-0.1, 0.54]
	Interaction	0.20	0.33	0.61	148.92	0.545	0.1 [-0.22, 0.42]

Notes: Effects: Main Effect of time, interaction effect of time and group; Estimate: Coefficient (beta) of an effect/predictor; SE: standard error of the estimate; t: test statistic; DF: degrees of freedom, P: P-value; Cohen’s d: effect size with 95% confidence interval.

For example, total AMT scores did not change significantly over time/during the study (t = 0.09, DF = 149, P = 0.932) and total AMT score changes did not differ significantly between the active and the sham TBS groups (t = -0.25, DF = 150, P = 0.803).

4.2 Prediction of AMT change

Linear regression models were set up with AMT deltas (week 12 - baseline) as dependent variables and a predictor and group as interacting independent variables. Predictors were the NEO-PI-R sum scores and HDRS baseline measure. Each combination of AMT measure and predictor was tested in a separate linear regression. A significant main effect means the variable predicts AMT changes, independent of group. A significant interaction means the variable predicts TBS efficacy. However, as there were no significant changes in AMT measures across time and no TBS effects on AMT measures (previous section), it is unlikely to have findings for the current analyses.

Predictor	Main effect				Interaction
Predictor	Estimate	SE	t	P	Estimate	SE	t	P
TOTAL_TMA
HDRS at baseline	-0.34	0.42	-0.81	0.418	0.34	0.66	0.51	0.610
Neuroticismo	0.01	0.10	0.06	0.952	-0.18	0.13	-1.38	0.171
Extroversao	0.01	0.10	0.14	0.886	0.09	0.12	0.75	0.456
Abertura	-0.01	0.08	-0.10	0.924	-0.03	0.11	-0.29	0.770
Amabilidade	-0.05	0.12	-0.44	0.662	0.06	0.15	0.41	0.683
Conscienciosidade	0.10	0.09	1.13	0.264	-0.06	0.12	-0.47	0.641
TOTAL_TMA_POS
HDRS at baseline	-0.12	0.13	-0.90	0.372	0.05	0.21	0.25	0.803
Neuroticismo	0.01	0.03	0.27	0.786	-0.01	0.04	-0.20	0.838
Extroversao	0.01	0.03	0.42	0.676	-0.01	0.04	-0.32	0.748
Abertura	0.02	0.03	0.55	0.581	-0.03	0.04	-0.76	0.448
Amabilidade	-0.04	0.04	-1.12	0.266	0.05	0.05	0.92	0.363
Conscienciosidade	0.03	0.03	0.86	0.392	-0.04	0.04	-1.02	0.311
TOTAL_TMA_NEG
HDRS at baseline	-0.14	0.14	-1.01	0.316	0.21	0.23	0.91	0.366
Neuroticismo	-0.01	0.04	-0.41	0.686	-0.04	0.05	-0.92	0.361
Extroversao	0.02	0.04	0.67	0.507	0.02	0.04	0.38	0.707
Abertura	-0.01	0.03	-0.32	0.748	0.01	0.04	0.34	0.733
Amabilidade	-0.05	0.04	-1.06	0.291	0.05	0.06	0.89	0.379
Conscienciosidade	0.04	0.03	1.19	0.237	-0.02	0.04	-0.57	0.569
TOTAL_TMA_Nu
HDRS at baseline	-0.08	0.19	-0.40	0.687	0.08	0.30	0.27	0.791
Neuroticismo	0.01	0.04	0.25	0.804	-0.13	0.06	-2.16	0.035
Extroversao	-0.02	0.05	-0.52	0.608	0.09	0.06	1.56	0.123
Abertura	-0.01	0.04	-0.35	0.725	-0.02	0.05	-0.35	0.730
Amabilidade	0.04	0.06	0.67	0.504	-0.03	0.07	-0.45	0.652
Conscienciosidade	0.04	0.04	0.87	0.389	0.01	0.06	0.18	0.859

Notes: Main Effect of time, interaction effect of time and group. Estimate: Coefficient (beta) of an effect/predictor; SE: standard error of the estimate; t: test statistic; DF: degrees of freedom, P: P-value.

4.3 Correlations between AMT and NEO-PI-R measures

Mean AMT values over the three time points were calculated per subject and then correlated with NEO-PI-R measures.

The first table shows Pearson’s correlations, and the second shows the P-values for each correlation.High correlations between different AMT measures are expected.

Pearson	TOTAL_TMA	TOTAL_TMA_POS	TOTAL_TMA_NEG	TOTAL_TMA_Nu	Neuroticismo	Extroversao	Abertura	Amabilidade
TOTAL_TMA_POS	0.87
TOTAL_TMA_NEG	0.90	0.76
TOTAL_TMA_Nu	0.90	0.67	0.70
Neuroticismo	-0.04	-0.05	-0.09	0.06
Extroversao	0.07	0.03	0.10	0.00	-0.41
Abertura	0.34	0.17	0.30	0.38	-0.03	0.39
Amabilidade	-0.04	-0.05	0.00	-0.05	-0.02	0.07	0.27
Conscienciosidade	-0.05	-0.06	0.02	-0.09	-0.50	0.29	-0.06	0.04

P-values	TOTAL_TMA	TOTAL_TMA_POS	TOTAL_TMA_NEG	TOTAL_TMA_Nu	Neuroticismo	Extroversao	Abertura	Amabilidade
TOTAL_TMA_POS	0.000
TOTAL_TMA_NEG	0.000	0.000
TOTAL_TMA_Nu	0.000	0.000	0.000
Neuroticismo	0.748	0.699	0.447	0.650
Extroversao	0.595	0.800	0.391	0.987	0.000
Abertura	0.004	0.153	0.012	0.001	0.789	0.001
Amabilidade	0.752	0.698	0.984	0.660	0.887	0.578	0.022
Conscienciosidade	0.691	0.641	0.884	0.473	0.000	0.015	0.633	0.722

4.4 TBS effects on HDRS

Before running predictive analyses, it makes sense to investigate if the treatment of interest was effective. It is easier to find predictors of TBS efficacy if TBS reduced depressive symptoms.

In the original sample of 108 subjects, TBS significantly improved depressive symptoms if all data until week 12 was included (P = 0.045), but was barely not significant when only data until week 6, the primary study endpoint, was analysed (P = 0.059).

In the subsequent predictive analyses, AMT and NEO-PI data are investigated as predictors of TBS response. Because of missing AMT and NEO-PI data, two different subsamples will be used for these analyses. It is interesting to see how the TBS effect on HDRS behaves in these subsamples.

A linear mixed-effects model was used to investigate if treatment was effective was in the two different subsamples used for the subsequent predictive analyses for AMT and NEO PI measures. Time was assumed to be linear on a natural logarithmic scale. HDRS-17 was the outcome, group and time were included as interacting fixed effects, and subject as random-intercept effect.

4.4.1 NEO PI subsample

## [1] "Week 12 as endpoint:"

##                              Estimate Std Error     df t value     P
## (Intercept)                     19.94      0.80 149.35   25.05 0.000
## conditionActive TBS             -0.10      1.10 149.31   -0.09 0.926
## time_log                        -2.81      0.31 452.12   -9.19 0.000
## conditionActive TBS:time_log    -0.85      0.42 452.08   -2.01 0.045

In the NEO PI subsample with week 12 as endpoint, results showed a reduction in HDRS-17 scores across time, independent of group (t(452) = -9.19, P < .001). There was a significant interaction of group and time (t(452) = -2.01, P = 0.045). This indicates that active TBS treatment was effective in reducing depressive symptoms.

(The other analyses in this section can be interpreted analogously.)

## [1] "Week 6 as endpoint:"

##                              Estimate Std Error     df t value     P
## (Intercept)                     20.47      0.74 155.25   27.68 0.000
## conditionActive TBS              0.07      1.02 155.25    0.07 0.944
## time_log                        -3.51      0.40 301.16   -8.83 0.000
## conditionActive TBS:time_log    -1.09      0.55 301.11   -1.98 0.048

4.4.2 AMT subsample

## [1] "Week 12 as endpoint:"

##                              Estimate Std Error     df t value     P
## (Intercept)                     19.98      0.76 162.47   26.45 0.000
## conditionActive TBS             -0.42      1.04 162.39   -0.40 0.687
## time_log                        -2.84      0.30 460.23   -9.36 0.000
## conditionActive TBS:time_log    -0.84      0.42 459.56   -2.01 0.044

## [1] "Week 6 as endpoint:"

##                              Estimate Std Error     df t value     P
## (Intercept)                     20.53      0.71 169.53   29.01 0.000
## conditionActive TBS             -0.32      0.98 169.50   -0.33 0.745
## time_log                        -3.57      0.40 307.70   -8.97 0.000
## conditionActive TBS:time_log    -0.99      0.55 307.16   -1.80 0.072

4.5 Prediction of HDRS (antidepressant response)

Predictors are AMT measures at baseline and all NEO PI measures, which were evaluated for HDRS changes (deltas) from baseline to endpoint using linear regression and for HDRS response using logistic regression (generalized linear model). For each predictor, separate models were set up with the outcome referring to Week 6 or 12 as endpoint. Group and predictor were included as interacting factors. A significant main effect of the predictor indicates that the predictor had an effect on HDRS changes/responses on the whole sample, independent of group. A significant interaction of the predictor and group is the “desirable” outcome: It indicates that this measure predicts TBS effectiveness.

Because of the big number of tests, it’s likely that some significant findings are “false positives”, which means they are significant based on chance alone. There are several ways to counteract this:

Reduce the number of tests based on theory
Use a correction for multiple comparisons. With the current number of tests, it seems unlikely they would stay significant after correction.

4.5.1 Predictors of HDRS change

Predictor	Main effect				Interaction
Predictor	Estimate	SE	t	P	Estimate	SE	t	P
Week 6
AMT total	0.06	0.16	0.38	0.707	-0.11	0.21	-0.50	0.618
AMT positive	0.00	0.44	-0.01	0.995	-0.14	0.68	-0.20	0.841
AMT negative	0.17	0.38	0.46	0.647	-0.27	0.61	-0.44	0.661
AMT neutral	0.16	0.36	0.45	0.657	-0.26	0.46	-0.58	0.567
Neuroticismo	0.00	0.08	-0.03	0.979	0.09	0.10	0.91	0.364
Extroversao	-0.06	0.08	-0.78	0.439	-0.05	0.10	-0.56	0.580
Abertura	-0.02	0.07	-0.37	0.715	-0.01	0.09	-0.12	0.903
Amabilidade	0.09	0.10	0.93	0.356	-0.06	0.12	-0.53	0.599
Conscienciosidade	0.10	0.08	1.33	0.189	-0.06	0.10	-0.60	0.553
Neuroticismo ansiedade	0.48	0.35	1.37	0.175	0.12	0.44	0.28	0.781
Neuroticismo raiva	0.26	0.29	0.89	0.377	-0.10	0.39	-0.25	0.802
Neuroticismo depressao	0.03	0.32	0.09	0.930	0.11	0.39	0.28	0.782
Neuroticismo embaraco	-0.31	0.31	-1.02	0.312	0.82	0.40	2.04	0.045
Neuroticismo impulsividade	-0.70	0.33	-2.15	0.035	0.68	0.39	1.76	0.082
Neuroticismo vulnerabilidade	0.16	0.27	0.60	0.548	-0.12	0.37	-0.33	0.745
Extroversao acolhimento	-0.15	0.25	-0.59	0.557	-0.36	0.32	-1.14	0.260
Extroversao gregarismo	0.13	0.27	0.46	0.644	-0.42	0.34	-1.24	0.219
Extroversao assertividade	0.13	0.30	0.44	0.659	-0.16	0.39	-0.40	0.693
Extroversao atividade	-0.22	0.34	-0.64	0.522	0.00	0.43	0.01	0.994
Extroversao busca de sensacoes	-0.77	0.35	-2.18	0.032	0.37	0.45	0.83	0.408
Extroversao emocoes positivas	-0.16	0.25	-0.65	0.516	-0.07	0.32	-0.23	0.822
Extroversao emocoes positivas extroversao	-0.07	0.11	-0.64	0.525	-0.04	0.14	-0.28	0.782
Abertura fantasia	-0.12	0.26	-0.46	0.644	-0.14	0.34	-0.43	0.670
Abertura estetica	0.07	0.30	0.23	0.822	-0.23	0.38	-0.61	0.545
Abertura sentimento	0.17	0.33	0.53	0.598	-0.23	0.44	-0.53	0.596
Abertura acoes variadas	0.05	0.30	0.15	0.880	0.00	0.39	0.01	0.996
Abertura ideias	-0.16	0.20	-0.77	0.441	0.08	0.29	0.26	0.796
Abertura valores	-0.22	0.28	-0.77	0.444	0.16	0.39	0.41	0.685
Amabilidade confianca	0.55	0.33	1.66	0.101	-0.52	0.38	-1.35	0.182
Amabilidade franqueza	0.20	0.30	0.67	0.508	0.20	0.43	0.46	0.647
Amabilidade altruismo	-0.12	0.30	-0.42	0.674	0.02	0.41	0.05	0.956
Amabilidade complacencia	0.34	0.34	1.02	0.310	-0.21	0.43	-0.48	0.630
Amabilidade modestia	0.41	0.33	1.23	0.221	-0.32	0.50	-0.64	0.527
Amabilidade sensibiliidade	-0.23	0.30	-0.78	0.441	0.02	0.45	0.04	0.967
Conscienciosidade competencia	0.13	0.31	0.41	0.679	-0.35	0.43	-0.81	0.423
Conscienciosidade ordem	0.49	0.33	1.51	0.137	-0.14	0.39	-0.36	0.721
Conscienciosidade senso de dever	0.07	0.32	0.22	0.825	0.09	0.45	0.21	0.835
Conscienciosidade esforco por realizacoes	-0.14	0.25	-0.56	0.574	0.08	0.37	0.21	0.837
Conscienciosidade autodisciplina	0.58	0.34	1.70	0.093	-0.52	0.40	-1.28	0.205
Conscienciosidade ponderacao	0.34	0.21	1.59	0.115	-0.14	0.30	-0.45	0.653
Week 12
AMT total	0.18	0.17	1.05	0.299	-0.42	0.24	-1.79	0.078
AMT positive	0.28	0.48	0.58	0.567	-1.15	0.75	-1.53	0.130
AMT negative	0.52	0.42	1.25	0.217	-1.08	0.68	-1.59	0.116
AMT neutral	0.31	0.40	0.76	0.448	-0.73	0.51	-1.44	0.153
Neuroticismo	-0.02	0.09	-0.27	0.789	0.09	0.12	0.76	0.448
Extroversao	-0.04	0.09	-0.47	0.640	-0.09	0.11	-0.75	0.453
Abertura	-0.06	0.08	-0.75	0.459	-0.04	0.10	-0.40	0.687
Amabilidade	0.11	0.11	1.00	0.320	-0.08	0.14	-0.55	0.586
Conscienciosidade	0.11	0.09	1.32	0.189	-0.04	0.11	-0.38	0.707
Neuroticismo ansiedade	0.43	0.41	1.06	0.293	0.20	0.51	0.40	0.689
Neuroticismo raiva	0.28	0.34	0.83	0.410	0.02	0.45	0.04	0.970
Neuroticismo depressao	0.08	0.37	0.22	0.830	-0.08	0.45	-0.17	0.865
Neuroticismo embaraco	-0.62	0.35	-1.78	0.079	1.20	0.45	2.66	0.010
Neuroticismo impulsividade	-0.79	0.37	-2.11	0.038	0.61	0.44	1.39	0.170
Neuroticismo vulnerabilidade	0.17	0.31	0.53	0.597	-0.14	0.43	-0.33	0.741
Extroversao acolhimento	-0.05	0.29	-0.16	0.873	-0.44	0.37	-1.18	0.241
Extroversao gregarismo	0.20	0.31	0.64	0.527	-0.48	0.39	-1.25	0.216
Extroversao assertividade	0.08	0.34	0.24	0.810	-0.42	0.45	-0.94	0.351
Extroversao atividade	-0.22	0.39	-0.56	0.578	0.15	0.50	0.30	0.764
Extroversao busca de sensacoes	-0.46	0.42	-1.12	0.268	0.01	0.53	0.02	0.986
Extroversao emocoes positivas	-0.24	0.28	-0.83	0.408	-0.02	0.36	-0.07	0.947
Extroversao emocoes positivas extroversao	-0.09	0.13	-0.72	0.474	0.00	0.16	-0.02	0.986
Abertura fantasia	-0.30	0.29	-1.02	0.311	0.08	0.38	0.21	0.832
Abertura estetica	0.02	0.33	0.07	0.944	-0.46	0.43	-1.07	0.290
Abertura sentimento	0.20	0.37	0.53	0.597	-0.48	0.50	-0.95	0.344
Abertura acoes variadas	-0.13	0.34	-0.37	0.715	0.05	0.45	0.11	0.914
Abertura ideias	-0.26	0.23	-1.12	0.265	-0.07	0.33	-0.21	0.833
Abertura valores	-0.19	0.32	-0.59	0.555	-0.25	0.44	-0.56	0.579
Amabilidade confianca	0.67	0.38	1.78	0.079	-0.59	0.44	-1.35	0.180
Amabilidade franqueza	0.30	0.35	0.86	0.392	0.09	0.50	0.18	0.856
Amabilidade altruismo	0.09	0.34	0.25	0.803	-0.21	0.48	-0.44	0.662
Amabilidade complacencia	0.03	0.38	0.08	0.938	0.30	0.50	0.61	0.547
Amabilidade modestia	0.41	0.38	1.08	0.283	-0.50	0.58	-0.86	0.391
Amabilidade sensibiliidade	-0.19	0.34	-0.57	0.573	-0.12	0.51	-0.23	0.819
Conscienciosidade competencia	0.31	0.36	0.87	0.388	-0.31	0.49	-0.63	0.528
Conscienciosidade ordem	0.40	0.38	1.07	0.290	-0.02	0.45	-0.04	0.967
Conscienciosidade senso de dever	0.16	0.37	0.42	0.673	-0.01	0.52	-0.03	0.979
Conscienciosidade esforco por realizacoes	-0.17	0.29	-0.58	0.566	0.32	0.42	0.77	0.443
Conscienciosidade autodisciplina	0.37	0.40	0.93	0.354	-0.37	0.47	-0.78	0.436
Conscienciosidade ponderacao	0.39	0.24	1.60	0.115	-0.03	0.35	-0.10	0.921

4.5.2 Predictors HDRS response

Response is defined as at least a 50% reduction in the HDRS score from baseline to endpoint. weeks 6 and 12 are analyzed as endpoints.

Predictor	Main effect			Interaction
Predictor	Odds ratio	z	P	Odds ratio	z	P
Week 6
AMT total	1.01	0.11	0.912	0.98	-0.21	0.834
AMT positive	1.05	0.31	0.757	0.96	-0.19	0.853
AMT negative	1.00	-0.02	0.981	0.93	-0.33	0.739
AMT neutral	1.00	0.02	0.982	0.99	-0.08	0.933
Neuroticismo	1.01	0.33	0.745	0.95	-1.18	0.236
Extroversao	1.04	1.25	0.212	1.01	0.35	0.728
Abertura	1.03	1.05	0.294	1.00	-0.03	0.980
Amabilidade	0.96	-1.09	0.274	1.05	1.05	0.292
Conscienciosidade	0.97	-1.07	0.284	1.05	1.24	0.214
Neuroticismo ansiedade	0.91	-0.69	0.492	0.88	-0.68	0.494
Neuroticismo raiva	0.89	-0.95	0.340	0.95	-0.32	0.750
Neuroticismo depressao	1.02	0.14	0.891	0.86	-1.00	0.316
Neuroticismo embaraco	1.19	1.36	0.174	0.71	-2.12	0.034
Neuroticismo impulsividade	1.45	2.19	0.028	0.71	-1.87	0.061
Neuroticismo vulnerabilidade	0.93	-0.74	0.459	1.15	1.05	0.294
Extroversao acolhimento	1.11	0.97	0.333	1.10	0.66	0.509
Extroversao gregarismo	0.95	-0.48	0.628	1.18	1.29	0.197
Extroversao assertividade	1.06	0.51	0.607	0.96	-0.29	0.772
Extroversao atividade	1.05	0.37	0.713	1.10	0.57	0.571
Extroversao busca de sensacoes	1.43	1.97	0.049	0.79	-1.09	0.275
Extroversao emocoes positivas	1.13	1.23	0.217	1.03	0.23	0.820
Extroversao emocoes positivas extroversao	1.05	1.01	0.312	1.03	0.53	0.598
Abertura fantasia	1.12	1.14	0.254	1.06	0.43	0.667
Abertura estetica	1.09	0.76	0.445	0.94	-0.47	0.640
Abertura sentimento	0.93	-0.57	0.566	1.16	0.93	0.353
Abertura acoes variadas	1.03	0.29	0.768	1.06	0.38	0.704
Abertura ideias	1.10	1.14	0.255	0.97	-0.25	0.801
Abertura valores	1.12	1.04	0.298	0.92	-0.60	0.549
Amabilidade confianca	0.76	-1.86	0.062	1.40	2.08	0.037
Amabilidade franqueza	0.84	-1.32	0.186	1.18	0.98	0.327
Amabilidade altruismo	1.01	0.13	0.896	1.05	0.33	0.739
Amabilidade complacencia	0.89	-0.86	0.392	1.03	0.21	0.837
Amabilidade modestia	0.89	-0.93	0.353	0.97	-0.14	0.891
Amabilidade sensibiliidade	1.15	1.06	0.287	0.98	-0.11	0.909
Conscienciosidade competencia	0.99	-0.06	0.952	1.27	1.39	0.164
Conscienciosidade ordem	0.76	-1.77	0.077	1.22	1.15	0.252
Conscienciosidade senso de dever	0.92	-0.70	0.484	1.22	1.19	0.233
Conscienciosidade esforco por realizacoes	1.07	0.66	0.512	0.95	-0.33	0.745
Conscienciosidade autodisciplina	0.90	-0.78	0.436	1.15	0.93	0.352
Conscienciosidade ponderacao	0.91	-1.05	0.295	1.13	1.02	0.307
Week 12
AMT total	0.96	-0.78	0.438	1.14	1.63	0.103
AMT positive	0.93	-0.43	0.664	1.23	0.87	0.385
AMT negative	0.95	-0.36	0.720	1.31	1.21	0.225
AMT neutral	0.86	-1.10	0.272	1.41	1.96	0.050
Neuroticismo	1.01	0.24	0.813	0.99	-0.15	0.884
Extroversao	1.01	0.29	0.768	1.02	0.46	0.643
Abertura	1.02	0.79	0.431	0.98	-0.50	0.620
Amabilidade	0.99	-0.24	0.814	1.00	-0.02	0.982
Conscienciosidade	0.98	-0.78	0.438	0.99	-0.16	0.876
Neuroticismo ansiedade	0.83	-1.37	0.172	1.00	-0.02	0.981
Neuroticismo raiva	0.91	-0.81	0.419	1.11	0.74	0.457
Neuroticismo depressao	1.01	0.09	0.931	1.01	0.09	0.929
Neuroticismo embaraco	1.34	2.07	0.038	0.69	-2.22	0.026
Neuroticismo impulsividade	1.25	1.61	0.107	0.87	-0.88	0.378
Neuroticismo vulnerabilidade	0.93	-0.74	0.458	1.13	0.90	0.369
Extroversao acolhimento	1.04	0.38	0.703	1.06	0.49	0.626
Extroversao gregarismo	0.98	-0.24	0.813	1.20	1.43	0.153
Extroversao assertividade	0.89	-1.02	0.307	1.15	0.95	0.344
Extroversao atividade	1.00	-0.03	0.978	0.94	-0.41	0.681
Extroversao busca de sensacoes	1.28	1.57	0.117	0.85	-0.88	0.378
Extroversao emocoes positivas	1.05	0.52	0.604	0.99	-0.06	0.950
Extroversao emocoes positivas extroversao	1.02	0.54	0.591	0.99	-0.18	0.859
Abertura fantasia	1.04	0.45	0.651	0.97	-0.22	0.827
Abertura estetica	1.02	0.14	0.890	1.00	0.01	0.993
Abertura sentimento	0.89	-0.93	0.352	1.15	0.86	0.393
Abertura acoes variadas	1.04	0.33	0.744	0.90	-0.71	0.479
Abertura ideias	1.10	1.17	0.244	0.93	-0.71	0.479
Abertura valores	1.18	1.47	0.141	0.90	-0.74	0.460
Amabilidade confianca	0.73	-2.10	0.036	1.41	2.08	0.037
Amabilidade franqueza	1.00	0.02	0.985	0.91	-0.63	0.528
Amabilidade altruismo	1.04	0.39	0.697	0.99	-0.09	0.925
Amabilidade complacencia	1.04	0.30	0.762	0.79	-1.44	0.151
Amabilidade modestia	0.90	-0.86	0.389	1.19	0.97	0.333
Amabilidade sensibiliidade	1.20	1.34	0.179	0.86	-0.85	0.396
Conscienciosidade competencia	0.98	-0.14	0.885	0.98	-0.15	0.878
Conscienciosidade ordem	0.86	-1.15	0.249	1.04	0.27	0.784
Conscienciosidade senso de dever	0.97	-0.28	0.777	0.99	-0.05	0.964
Conscienciosidade esforco por realizacoes	1.05	0.49	0.625	0.86	-1.11	0.269
Conscienciosidade autodisciplina	0.90	-0.78	0.434	1.09	0.59	0.557
Conscienciosidade ponderacao	0.95	-0.67	0.500	0.94	-0.50	0.618

Notes: Main Effect of time, interaction effect of time and group. Odds ratio: The change in odds of response for a one-unit change in the predictor variable; Z: test statistic; P: P-value. If the interaction is significant, the main effect cannot be interpreted.

4.5.3 Predictors HDRS remission